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Direct-acting antiviral agents (DAAs) have revolutionized treatment of chronic hepatitis C in patients with normal glomerular filtration rate (GFR). Rukaiyah Adams John Russell Rex Kim Rick Miller, Jr. Tobias Read Steve Rodeman Vice Chair Member Member Member State Treasurer PERS Director OREGON INVESTMENT COUNCIL Agenda February 1, 2017 9:00 AM Oregon State Treasury Investment Division 16290 SW Upper Boones Ferry Road Tigard, OR 97224 Time A. To investigate the tolerability of nebulized lidocaine compared to conventional lidocaine administration via syringe through the working channel of the bronchoscope in patients undergoing bronchoscopy. Based on several standard modules, our turnkey solutions serve many busines cases from R&D to volume production, enabling a fast time to market & optimized TCO. Tobias Müller Bilateral severe vision loss is a dramatic illness that requires extended diagnostics and immediate therapy. Determination of the SAS- frequence in patients with bronchial carcinoma. Respir Res. Einleitung Der Hepatitis C Genotyp 1 ist der häufigste Genotyp in West- und Zentraleuropa. Use of lidocaine to prevent postoperative coughing after partial laryngectomy: comparison of three delivery methods. The purpose of our study was to investigate how to differentiate between Gd-EOB-enhancing HCAs and focal nodular hyperplasias (FNHs). (DOC), Odds ratios and corresponding p-values for predicting failure of SVR using logistic regression models. Nebulized dexmedetomidine-lidocaine inhalation as a premedication for flexible bronchoscopy: a randomized trial. The overall aim of my research is to gain a better understanding of our body’s natural defense mechanisms against viruses, which may help us to eventually develop new antiviral therapies. IL28B gene polymorphism is the best baseline predictor of response to interferon alfa-based antiviral therapies in chronic hepatitis C. Recently, a new IFN-L4 polymorphism was identified as first potential functional variant for induction of IL28B expression. Hardware Boards. The visualizations for "Tobias Müller, Großholbach, Germany" are provided by North Data and may be reused under the terms of the Creative Commons CC-BY license. ER stress occurs when protein folding capacity is exceeded. , 2005 Sep;128(3):1756-60. doi: 10.1378/chest.128.3.1756. 2018 Nov 21;19(1):227. doi: 10.1186/s12931-018-0926-5. Methods: tobmueller@ukaachen.de. With the aging of the hepatitis C virus (HCV)-infected patient cohort and the availability of highly effective and tolerable treatment regimens, an increasing number of elderly patients are now eligible for HCV therapy. CAS Article Google Scholar … Müller T, Cornelissen C, Dreher M. Nebulization versus standard application for topical anaesthesia during flexible bronchoscopy under moderate sedation - a randomized controlled trial. J Thorac Dis. -Effects of Local Anesthetics on Smooth Muscle Tissue in Rat Trachea: An In Vitro Study. This Article explores whether the revision of the ICC Rules has advanced the process. Meine Texte sind im Süddeutschen Magazin, der Weltwoche und dem Guardian erschienen, ich schreibe regelmässig für die österreichische Tageszeitung Der Standard und das Magazin Falstaff. Essen, Trinken, Kochen, Schreiben. Would you like email updates of new search results? Low-density lipoprotein receptors have been termed candidate receptors for HCV-LDL complexes. J Anesth. Guidelines for diagnostic flexible bronchoscopy in adults: Joint Indian Chest Society/National College of chest physicians (I)/Indian association for bronchology recommendations. Tobias Müller weiß, wie die Vorarlberger Spezialität schmecken muss. View Laszlo Tobias’ profile on LinkedIn, the world’s largest professional community. Background: View Tobias Müller’s profile on LinkedIn, the world’s largest professional community. Zusammenfassung 2018 Nov 21;19(1):227. doi: 10.1186/s12931-018-0926-5. Clipboard, Search History, and several other advanced features are temporarily unavailable. IRCCS Ospedale Casa Sollievo della Sofferenza, University Medical Center Hamburg - Eppendorf, Institut für Interdisziplinäre Medizin Hamburg, Klinik für Allgemein-, Viszeral- und Gefäßchirurgie, Klinik für Allgemein- Viszeral- und Transplantationschirurgie, Dept. This site needs JavaScript to work properly. Interleukin 28B (IL28B)... Genetic variation in the interleukin 28B (IL28B) gene has been associated with the response to interferon-alfa/ribavirin therapy in hepatitis C virus (HCV) genotype 1-infected patients. We compared distributions of PNPLA3 genotypes i... Pattern recognition receptors (PRRs) orchestrate the innate immune defence in human biliary epithelial cells (BECs). Erdem AO, Erel VK, Girit Ö, Erdoğan H, Özkısacık S, Yazıcı M. Turk Thorac J. (TIF). A T-helper (Th) 2 cell cytokine profile predominates in liver tissues from these patients. A recent study proposed a 32-base pair deletion in the CC-chemokine receptor 5 (CCR5) gene (CCR5-Δ32) interacting with the IL28B polymorphisms to influence spontaneous HCV clearance. Hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis. The aim of this study was to clarify the role of... Background & aims: Long-term consequences are the development of liver cirrhosis and hepatocellular carcinoma. Sorry, you need to be a researcher to join ResearchGate. Dreher M, Cornelissen CG, Reddemann MA, Müller A, Hübel C, Müller T. Nebulized versus standard local application of lidocaine during flexible bronchoscopy: a randomized controlled trial. DHCR7 Epidemiological data has only been provided from tertiary centres. The expression of (a) phospho-IRE1, total IRE1, phospho- eIF2α and total eIF2α an... JFH1 HCV fully infective cell system: (a) Titration of viral infection was done and TCID50 was calculated as described in the methods. Nebulized lidocaine alone or combined with fentanyl as a premedication to general anesthesia in spontaneously breathing pediatric patients undergoing rigid bronchoscopy. Browse the most recent Oregon obituaries and condolences. RNA and protein were extracted on the indicated times and assessed for (b) HCV RNA (c) NS5A by real-time PCR and western blotting respectively. Join ResearchGate to find the people and research you need to help your work. About. Nebulized versus Standard Local Application of Lidocaine during Flexible Bronchoscopy: A Randomized Controlled Trial ... Manuel Armin Reddemann, Annegret Müller, Christian Hübel, Tobias Müller. The patients will be screened at home for 1 night with the ApneaLink device by ResMed. Ziele & Methoden: Wir bestimmten die PSC-IgG4 Pravalenz in zwei grosen unabhangi... To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C. He married Anna Miller on 16 June 1800. Endobronchial administration of local anesthetics such as lidocaine is often used for cough suppression during bronchoscopy. Privacy, Help Infectious HCV particles bind to host lipoproteins such as low-density lipoproteins (LDL). Connectivity. The genetic background of alcoholic liver diseases and their complications are increasingly recognized. We therefore retrospectively included 40 HCAs c... Ecto-nucleotidase triphosphate diphosphohydrolase-2 (NTPDase2) is an ecto-enzyme that is expressed on portal fibroblasts in the liver that modulates P2 receptor signaling by regulating local concentrations of extracellular ATP and ADP. Celebrate and remember the lives we have lost in Oregon. , and ‎Download apps by Tobias Mueller, including AquaNautic Pro. IL28B polymorphisms strongly predict spontaneous and treatment-induced clearance of hepatitis C virus (HCV) infection. Bethesda, MD 20894, Copyright Endpoints were consumption of lidocaine and sedative drugs, as well as patient tolerance and safety. Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1α-hydroxylase (CYP27B1-1260 rs10877012) and the response to treatment with pegylated interferon-α (PEG-... Unlabelled: doi: 10.4103/lungindia.lungindia_108_19. Conclusion: Hepatocellular adenomas: is there additional value in using Gd-EOB-enhanced MRI for subtype differentiation? Bring your services to over 450,000 developers. Hepatitis C virus (HCV) uses several host factors to infect and replicate in human hepatocytes. Nebulized lidocaine in the treatment of intractable cough. Tobias MÜLLER | Cited by 2,487 | of University Hospital RWTH Aachen, Aachen | Read 101 publications | Contact Tobias MÜLLER Evaluation of Muscarinic Acetylcholine Receptor Type 3 Gene Polymorphisms in Patients with Primary Biliary Cholangitis and Primary Sclerosing Cholangitis, Real World Experience of Prescribing Tenofovir Alafenamide for Chronic Hepatitis B Patients in Germany, Assoziation des Polymorphismus rs7000921 im INTS10-Gen mit der Leberzirrhose bei kaukasischen Patienten mit chronischer Hepatitis B, Wirksamkeit und Sicherheit einer Sofosbuvir-Monotherapie bei Patienten mit chronischer Hepatitis E-Die HepNet SofE Studie, Persistenz von HCV Resistenz-assoziierten Substitutionen in NS3, NS5A und NS5B nach einem DAA Therapieversagen, Evolution of HCV patient characteristics and DAA regimens in the German Hepatitis C Registry (DHC-R) in 2014 and 2015, PS-179-Analysis of long-term persistence of HCV resistance-associated substitutions within NS, NS5A and NS5B in genotype 1 and 3 after DAA treatment failure, LBO-04-Efficacy and safety of sofosbuvir monotherapy in patients with chronic hepatitis E-The HepNet SofE pilot study, Hepatitis C therapy with direct antiviral agents in patients with advanced chronic kidney disease: real-world experience of the German Hepatitis C-Registry (Deutsches Hepatitis C-Register), Alcohol and Cannabis Consumption Does Not Diminish Cure Rates in a Real-World Cohort of Chronic Hepatitis C Virus Infected Patients on Opioid Substitution Therapy—Data From the German Hepatitis C-Registry (DHC-R), Deutsches Hepatitis C-Register (DHC-R) – eine Zwischenbilanz 4 Jahre nach Zulassung direkt antiviraler Substanzen (DAAs), Outcomes and costs of treating hepatitis C patients with second-generation direct-acting antivirals: results from the German Hepatitis C-Registry, Effectiveness and Safety of Direct-Acting Antiviral Combination Therapies for Treatment of Hepatitis C Virus in Elderly Patients: Results from the German Hepatitis C Registry, Die Auswirkung frühzeitiger Corticosteroidtherapie bei Patienten mit unklarer akuter Hepatitis, Clinical significance of detectable and quantifiable HCV RNA at the end of treatment with ledipasvir/sofosbuvir in GT1 patients, Impact of early corticosteroid treatment in patients with indeterminate acute severe hepatitis, Charakteristische ALT Verläufe nach Steroid Reduktion bei akuter Hepatitis ermöglichen eine Differenzierung von AIH und DILI, Serum IgG4 and long term outcome in patients with primary biliary cholangitis treated with ursodeoxycholic acid, Apolipoprotein E (APOE) allele frequencies in chronic and self-limited hepatitis C suggest a protective effect of APOE4 in the course of HCV infection, Einfluss des Apolipoprotein E Polymorphismus auf den Verlauf der Hepatitis C Virus (HCV) Infektion, Keratin-8-Mutationen prädisponieren nicht zur Entwicklung chronischer Lebererkrankungen insbesondere nicht zur kryptogenen Cirrhose, Predictive Value of Interferon-Lambda Gene Polymorphisms for Treatment Response in Chronic Hepatitis C, Validierung etablierter International Autoimmune Hepatitis Group (IAIHG) Diagnose-Scores in 246 Patienten mit gut charakterisierter autoimmuner Hepatitis in einer deutschen Universitätsklinik, The impact of elevated serum IgG4 levels in patients with primary sclerosing cholangitis, Polymorphisms in Melanoma Differentiation-Associated Gene 5 Link Protein Function to Clearance of Hepatitis C Virus, A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease, Evaluation of Liver Disease Progression in the German Hepatitis C Virus (1b)-Contaminated Anti-D Cohort at 35 Years After Infection, CCAAT/Enhancer-Binding Protein Homologous (CHOP) Protein Promotes Carcinogenesis in the DEN-Induced Hepatocellular Carcinoma Model, Influence of the CXCL1 rs4074 A Allele on Alcohol Induced Cirrhosis and HCC in Patients of European Descent, Association of IFNL3 rs12979860 and rs8099917 with Biochemical Predictors of Interferon Responsiveness in Chronic Hepatitis C Virus Infection, Assoziation zwischen IFNL3 Polymorphismen und klinischen Prädiktoren des Ansprechens auf eine interferon-basierte antivirale Therapie bei chronischer Hepatitis C, CCR5-Δ32 genotype does not improve predictive value of IL28B polymorphisms for treatment response in chronic HCV infection, Increased T-Helper 2 Cytokines in Bile From Patients With IgG4-Related Cholangitis Disrupt the Tight Junction-Associated Biliary Epithelial Cell Barrier, Untersuchungen zur Bedeutung erhöhter IgG4 Serumspiegel in zwei großen unabhängigen europäischen Kohorten mit 345 Patienten mit primär sklerosierender Cholangitis (PSC), A Genetic Validation Study Reveals a Role of Vitamin D Metabolism in the Response to Interferon-Alfa-Based Therapy of Chronic Hepatitis C, Combined effects of different interleukin-28B gene variants on the outcome of dual combination therapy in chronic hepatitis C virus type 1 infection, Hepatocytes That Express Variants of Cyclophilin A Are Resistant to HCV Infection and Replication, 912 APOLIPOPROTEIN E4 ALLELE PROTECTS FROM CHRONIC HCV INFECTION, The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C, TRAIL receptor I (DR4) polymorphisms C626G and A683C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients, The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients, The PNPLA3 rs738409 148M/M Genotype Is a Risk Factor for Liver Cancer in Alcoholic Cirrhosis but Shows No or Weak Association in Hepatitis C Cirrhosis, Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis, HCV Causes Chronic Endoplasmic Reticulum Stress Leading to Adaptation and Interference with the Unfolded Protein Response, IL28B, HLA-C, and KIR Variants Additively Predict Response to Therapy in Chronic Hepatitis C Virus Infection in a European Cohort: A Cross-Sectional Study, TH2 Zytokine wie IL-4 und IL-13 beeinträchtigen die Barrierefunktion und die Wundheilung humaner biliärer Epithelzellen (BECs), Kombination von IL28B Varianten (SNPs rs12979860 und rs8099917) verfeinert die Vorhersage für ein dauerhaftes Therapieansprechen bei chronischer Hepatitis C Virus (HCV)-Infektion, 232 TRAIL RECEPTOR I POLYMORPHISMS C626G AND A638C ARE ASSOCIATED WITH AN INCREASED RISK FOR THE DEVELOPMENT OF HEPATOCELLULAR CARCINOMA (HCC) IN HCV-INFECTED PATIENTS, 1304 TH2 CYTOKINE-MEDIATED BILIARY EPITHELIAL CELL (BEC) BARRIER DYSFUNCTION MAY CONTRIBUTE TO IMMUNOGLOBULIN G4 (IGG4) ASSOCIATED SCLEROSING CHOLANGITIS (IAC), 1157 NUCLEOSIDE TRANSPORTER SLC28A2/3 AND SLC29A1/2 GENETICS: PROTECTION AGAINST ANAEMIA IN CHRONIC HEPATITIS C PATIENTS RECEIVING RIBAVIRIN, 1358 DISTINCT, ALCOHOL-MODULATED EFFECTS OF PNPLA3 GENOTYPE ON PROGRESSION OF CHRONIC HEPATITIS C, Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients, A Duffy antigen receptor for chemokines (DARC) polymorphism that determines pro-fibrotic chemokine serum concentrations is not directly associated with severity of hepatitis C infection, Distinct, alcohol-modulated effects of PNPLA3 genotype on progression of chronic hepatitis C, Role of nucleoside transporters SLC28A2/3 and SLC29A1/2 genetics in ribavirin therapy, Prognose Untersuchungen zum Langzeitverlauf der primär sklerosierenden Cholangitis (PSC), Bedeutung von IL28B Gen Polymorphismen bei Hepatitis C Virus Genotyp 2 und 3 infizierten Patienten, Gestörte Endotoxin Toleranz in Gallengangsepithelien bei Patienten mit fortgeschrittener primär sklerosierender Cholangitis (PSC), Prävalenz erhöhter Immunglobulin G4 (IgG4) Konzentrationen bei Patienten mit chronisch-entzündlichen Lebererkrankungen unterschiedlicher Ätiologie, Innate barriers of respiratory virus infections, Department of General, Visceral and Transplantation Surgery. Chemokines play important roles in HCV-induced liver fibrosis. Join ResearchGate to contact this researcher and connect with your scientific community. , and HCV-related hepatocellular carcinoma development, considering the SCCS as case-control study. In dieser Arbeit werden die Veränderungen der Baselinecharakteristika von 17 093 HCV-Patienten mit Genotyp 1a/1b, die im Zeitraum 2004–2018 in Deutschland antiviral therapiert wurden, analysiert. What We Do. Paediatr Anaesth. Laszlo has 9 jobs listed on their profile. In patients with chronic hepatitis C virus (HCV) infection, several variants of the interleukin-28B (IL28B) gene have been shown to correlate significantly with a sustained virologic response (SVR). However, there are little data on the efficacy and safety of this approach, or on the consumption of sedative drugs and lidocaine during nebulized administration. Ecosystem. eCollection 2019. Ich bin freier Journalist und als solcher bemüht, viel unterwegs zu sein, sei es in China, Mexiko, den USA oder Österreich. We retrospectively identified 104 consecutive patients (75 males; mean age 41.98 ± 12.5 years) with confirmed diagnosis of PSC who underwent 227 gadoxetic acid... Zusammenfassung Background: Clinical practice guidelines for patients with primary biliary cholangitis (PBC) have been recently revised and implemented for well-established response criteria to standard first-line ursodeoxycholic acid (UDCA) therapy at 12 months after treatment initiation for the early identification of high-risk patients with inadequate treatment... Purpose: Aim: We evaluated whether the interplay of both IFNL3 polymorphisms rs12979860 and rs809... Primers for SNP genotyping assays. Cyclophilin A (CypA) is required for viral replication, and CypA inhibitors are in development. HuH7.5.1 hepatoma cells were infected with the HCV-JFH1 virus. He died on 4 May 1847, in his hometown, at the age of 71. derstandard.at. The importance of three IL28B single nucleotide polymorphisms (rs8099917, rs12980275 and rs12979860) for HCV genotype 2/3-infected patients is unknown. Prevention and treatment information (HHS). A common polymorphism in the neurocan (NCAN) gene, which is known to be expressed in neuronal tissue, has been identified as a risk factor for non-alcoholic fatty liver disease (NAFLD). Madan K, Biswal SK, Tiwari P, Mittal S, Hadda V, Mohan A, Khilnani GC, Guleria R. Lung India. To explore the role of CHOP in hepatocarcinogenesis, we induced hepatocellular carcinoma (HCC) in wild type (wt) and CHOP knockout (KO) mice usin... CXCL1 (CXC chemokine-ligand-1) is a ligand for CXC chemokine receptor 2 expressed on hepatic stellate cells (HSC). GC BLE, WiFi, Cellular, LoRaWAN and more. Einleitung In Deutschland sind mehr als 250 000 Patienten an einer chronischen Hepatitis C (CHC) erkrankt. This study investigated RASs before and after DAA failure in different genotype 4 subtypes and evaluated retreatment efficacies. FOIA The standard of hepatitis C antiviral therapy combines pegylated interferon-α with ribavirin. Here, we studied whether the PNPLA3 rs738409 polymorphism also affects predisposition to hepatocellular carcinoma (HCC). Investigating the evolution of the DAA utilization patterns and treatment outcomes could... Background: Tobias Muellers, of Wisconsin-Platteville, pole vaults while competing in the Hep during the Division III Men's and Women's Indoor Track & Field Championships held at the Birmingham CrossPlex on... Get premium, high resolution news photos at Getty Images 2013 May;23(5):429-34. doi: 10.1111/pan.12081. The aim of this study was to anal... Background & aims: Andhim – new boys in town It was spring 2010 when the cologne natives decided to kick their ass into gear and get out of their Studio to bring their beats to the world. However, patients with impaired kidney function have been excluded from several clinical trials. Become a partner. University students and faculty, institute members, and independent researchers, Technology or product developers, R&D specialists, and government or NGO employees in scientific roles, Health care professionals, including clinical researchers, Journalists, citizen scientists, or anyone interested in reading and discovering research.

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