The relationship between oxidative stress and cardiac stiffness is thought to involve modifications to the giant muscle protein titin, which in turn can determine the progression of heart disease. Voges, 2007: Genetische Analyse von Heterosis im jüngsten Stadium einer Pflanze, als Embryo, am Beispiel der Fababohne (, Franziska Roth, 2010: Evaluierung von Winterackerbohnen als Zwischenfrucht für eine ökologische Biogasproduktion. Rudolf-Schwander-Str. To expand the spectrum of bicaudal D, Drosophila, homologue 2 (BICD2) gene-related diseases, which so far includes autosomal dominant spinal muscular atrophy with lower extremity predominance 2 and hereditary spastic paraplegia due to mutations in the BICD2 gene. Familial atrial septal defect (ASD) has previously been attributed primarily to mutations in cardiac transcription factors. Objective: This file contains the Supplemental Table for Hamdani, Herwig, Linke, Biophys Rev. He has written four works of comparative literature and psychology of art, now considered standards of their genre. Die Staatsanwaltschaft Göttingen sieht mit Blick auf die Akten über „Linksmotivierte“ keinen Anfangsverdacht bei Mitarbeitern des Göttinger Staatsschutzes. A personal tribute to Johann Caspar Rüegg (1930–2018): milestones of muscle research, JACBTS Gotzmann Linke Published SupplFigure, Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis, Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1, Acute stimulation of the soluble guanylate cyclase does not impact on left ventricular capacitance in normal and hypertrophied porcine hearts in vivo, P497Altered myocardial function and perfusion in a swine model of diastolic dysfunction with multiple co-morbidities, Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening, Stretch-induced compliance: A novel adaptive biological mechanism following acute cardiac load, Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease, Genetically Engineered Human Stem-Cell Derived Cardiomyocytes to Investigate the Function of Cronos Titin, Quantifying the Titin Contribution to Muscle Force Generation using a Novel Method to Specifically Cleave the Titin Springs in Situ, Supplementary Figures&Table Nat-Commun Revision Final corrected, Titin Truncation Position Determines Propensity for Dilated Cardiomyopathy, Impaired Ventricular Relaxation and Passive Stiffness in Zebrafish, Impact of cGMP-PKG Pathway Modulation on Titin Phosphorylation and Titin-Based Myocardial Passive Stiffness, Placenta-Derived Adherent Stromal Cells Improve Diabetes Mellitus-Associated Left Ventricular Diastolic Performance: Placenta Stromal Cells and Diastolic Relaxation, Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function, Supplementary Figure S1 for Unger et al., Acta Neuropathol Commun. Whether TTNtv are sufficient to cause DCM or require a second hit for DCM manifestation is an important clinical issue. Recent studies have revealed numerous mutations in the FLNC gene causing familial and sporadic myopathies and cardiomyopathies with marked clinical variability. With the MICOS complex, OPA1 and the F 1 F o -ATP synthase, key players of cristae bio … Max Planck Institute for Solar System Research. The giant sarcomere protein titin is important in both heart health and disease. Bei Vielzellern sind die Skelettmuskeln für die Fortbewegung zuständig. However, recent evidence suggests that AVR outcome can be improved if performed earlier. Protein kinase D (PKD) enzymes play crucial roles in regulating myocardial contraction, hypertrophy, and remodeling. The giant protein titin performs structure-preserving functions in the sarcomere and is important for the passive stiffness (Fpassive) of cardiomyocytes. Academician at Göttingen Academy of Sciences, Fellow of the International Society for Heart Research (ISHR), Franz Maximilian Groedel Research Prize of the German Cardiac Society, Heisenberg Fellowship from German Research Foundation. Using intravit... Background: 1984 - 1989 Universities of Tübingen, Munich and Göttingen, law studies. Aims: The heart is constantly challenged with acute bouts of stretching or overload. Research focus on the solar system with its planets and moons, comets and asteroids, and of course the Sun. Languages. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. We combined a geno... Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. Here, we show that diastolic dysfunction in patients with HFpEF is associated with a cardiac deficit in nicotinamide adenine dinucleotide (NAD ⁺ ). The last decade has seen enormous progress in our understanding of how titin molecular elasticity is modulated in a dynamic manner to help cardiac sarcomeres adjust to the varying hemodynamic demands on the heart... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. Join ResearchGate to find the people and research you need to help your work. Mustapha Arbaoui, 2007: Detailed genetic analysis of faba bean, Lamiae Ghaouti, 2007: Comparison of pure line cultivars with synthetic cultivars in local breeding of faba bean (, Susanne Dieckmann geb. Reminiscent of Myo18b, Myo18a was highly exp... Cardiac functionality is dependent on a balanced protein turnover. Seif Eldin Gasim, 2003: Winter-hardy faba bean: Applied genetic research on the reproductive mode of the European gene pool. Cooperation with IAV Hassan II (, Reproductive features and vicine content of faba bean (, Drought tolerance, marker application, faba bean (, Awadallah Abdalla Abdelmula, 1999: Genetic improvement of drought tolerance in faba beans, Hilke M. Riemer, 1999: Nmin nach Ernte: Genotypische Variation in aktiuellem Material von Ackerbohnen (, Jens Christian Vaupel, 1999: Neue CMS-Systeme für die Produktion von Minor x Major-Hybridsorten bei, Memen Surahman, 2001: Detailed genetic analysis of a wide faba bean (, Anja Kramer, 2002: Untersuchungen zum biotechnologisch unterstützten Gentransfer bei der Ackerbohne, Andi Wijaya, 2003: Towards interspecific hybridization in, Mahmoud Mohamed Zeid, 2003: Analysis of genetic diversity based on molecular markers (AFLP) and of heterosis in faba bean (. 234th ENMC International Workshop: Chaperone dysfunction in muscle disease Naarden, The Netherlands, 8-10 December 2017. Anbieter: Volksbank Kassel Göttingen eG. Richtige Adressen und Telefonnummern finden! Band aus Göttingen. Auf LinkedIn können Sie sich das vollständige Profil ansehen und mehr über die Kontakte von Wolfgang Link und Jobs bei ähnlichen Unternehmen erfahren. The elasticity of muscle is principally determined by the I-band region of titin, consisting of 40-100 immunoglobulin-like (Ig) domains and Increased titin-dependent cardiomyocyte tension is a hallmark of heart failure with preserved ejection fraction (HFpEF) associated with type-2 diabetes mellitus (T2DM). So-called ‘desminopathies’ are disorders due to pathogenic variants in the DES gene and are associated with skeletal myopathies and/or various types of cardiomyopathies. Sorry, you need to be a researcher to join ResearchGate. Universität Göttingen. We show that under mechanical... Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and intractable form of cardiac decompensation commonly associated with diastolic dysfunction. 205 likes. Erstes Album [wolf:gang] 25.08.18 TTNtv are also encountered in [sim]1% of the general population, where they may be silent, perhaps reflecting allelic factors. The sarcomeric troponin-tropomyosin complex is a critical mediator of excitation-contraction coupling, sarcomeric stability and force generation. We generated a zebrafish model of an A-band TTNtv identified in 2... BACKGROUND:Truncating variants in the TTN gene (TTNtv) are common in patients with dilated cardiomyopathy (DCM) but also occur in the general population. Fraktion Göttinger Linke Neues Rathaus, Zi. We show extensive translational control of cardiac gene expression, which i... Randomized clinical trials initially used heart failure (HF) patients with low left ventricular ejection fraction (LVEF) to select study populations with high risk to enhance statistical power. Göttingen. Recent reports suggest that mammalian embryonic coronary endothelium (CoE) develops from the sinus venosus and ventricular endocardium. Professor Dr. Wolfgang Link, Abteilung Zuchtmethodik der Pflanze, Carl-Sprengel-Weg 1, 37075 Göttingen Finde 12 Profile von Wolfgang Link mit aktuellen Kontaktdaten ☎, Lebenslauf, Interessen sowie weiteren beruflichen Informationen bei XING. 1984: Dr. rer. Dezember 2015 in Lenglern) war ein deutscher Arzt und Hochschullehrer. E-Mail: dialog@vobakg.de . Participation in “Cells in Motion” Research interests: muscle cytoskeletal dynamics, biomolecular and cellular force measurements, atomic force microscopy, cardiomyocyte contractility and elasticity in health and disease, induced pluripotent stem cell-derived cardiomyocytes Papers in the research focus “cell dynamics and imaging” papers by Wolfgang A. Linke Experimental data indicate that stimulation of the nitric oxide-soluble guanylate cyclase(sGC)-cGMP-PKG pathway can increase left ventricular (LV) capacitance via phosphorylation of the myofilamental protein titin. Wolfgang Rode Innenarchitekt in Göttingen im Branchenbuch von meinestadt.de - Telefonnummer, Adresse, Stadtplan, Routenplaner und mehr für Wolfgang Rode Innenarchitekt Göttingen Methods Sie werden durch elastische Titinfilamente zusammengehalten. : 0561 7893-0. application of PLacenta-eXpanded (PLX) MSC-like cells (PLX) improves LV diastolic relaxation in streptozotocin (STZ)-induced diabetic mice and i... Myopathies encompass a wide variety of acquired and hereditary disorders. Cuvillier Göttingen (in Zusammenarbeit mit. Erstes Album [wolf:gang] 25.08.18 Ahmed Sallam, 2014: Detailed genetic approach to improve frost tolerance of German winter faba beans. Posttranslational modifications of titin from cardiac muscle: how, where and what for? Professor of Physiology and Department Chair, Adjunct Professor of Cardiac Mechanotransduction, Professor and Chair of Cardiovascular Physiology, Titin Gene and Protein Functions in Passive and Active Muscle, Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes, Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin, Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx), Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle, Nicotinamide for the treatment of heart failure with preserved ejection fraction, Graded Titin Cleavage Uncovers the Protein's Role for Sarcomere Structure and Force Generation of Contracting Muscle, Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism, Functional characterization of novel alpha-helical rod domain desmin (DES) pathogenic variants associated with dilated cardiomyopathy, atrioventricular block and a risk for sudden cardiac death, The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease, Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation, Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs. Fax: 0561 7893-1311. Breeding Research Nursery agric. Desmin is the major intermediate filament (IF) protein in human heart and skeletal muscle. Here, we use a novel titin-cleavage (TC) mouse model that allows specific and rapid cutting of elastic titin to quantify how titin-based forces define myocyte ultrastructure and mechanics. Jede Zelle besitzt ein verzweigtes Netzwerk von... Muskelkraft und -bewegung beruhen auf molekularen Prozessen in den kontraktilen Bausteinen der Muskelzellen, den Sarkomeren. Traditionally aortic valve replacement (AVR) has been recommended immediately after the onset of heart failure (HF) symptoms. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors, such as the chaperone Hsp90. nach Vereinbarung. 1. However, this use of LVEF in clinical trials has led to oversimplification of the scientific view of a complex syndrome. Winda Puspitasari, 2017: Association analyses to genetically study reproduction and seed quality features of faba bean (. Methods: 2017 Jun;9(3):225-237. doi: 10.1007/s12551-017-0263-9. Berufserfahrung, Kontaktdaten, Portfolio und weitere Infos: Erfahr mehr – oder kontaktier Wolfgang H. Geiger direkt bei XING. Here, we characterise the molecular stru... Background -Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modelling, drug screening, and heart repair. International space missions with ESA and NASA. Die Aktin- und Myosinfilamente treten durch Bildung bzw. A therapeutic dilemma is that the use of positive inotropic agents, such as catecholamines or phosphodiesterase-inhibitors, is associated with increased mortality. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Mesenchymal stromal cells (MSC) have cardiac-protective properties. Er leitete von 1977 bis 2014 das Institut für Humangenetik der Medizinischen Fakultät der Universität Göttingen. Here we show that homozygous deletion (homozygous tm1a, tm1b or tm1d alleles) of Myo18a in mouse is embryonic lethal. Wolfgang. Here, we ha... Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease. Although several studies in non-mammalian vertebrates have proven that extracardiac endothelial cells also participate in CoE development, the contribution of such cells to mammalian CoE is regarded to be minor and... Elucidating the biological mechanisms behind increased myocardial compliance following acute myocardial stretching and their role in cardiac diastolic (dys)function. Left atrial (LA) compliance and contractility influence left ventricular stroke volume. The ability to generate patient-specific induced pluripotent stem cells (iPSCs) provides a unique opportunity for modeling heart disease in vitro. Daniel Siebrecht-Schöll, 2019: Breeding analysis of eight winter faba bean genotypes for mixed cropping with winter wheat. The Sydney Heart Bank (SHB) is one of the largest human heart tissue banks in existence. So far, only a limited number of DES pathogenic variants have been identified... A detailed description of pathophysiological effects that viruses exert on their host is still challenging. The present work aimed to evaluate the early myocardial changes of DOXO-induced cardiotoxicity. Sehen Sie sich das Profil von Wolfgang Link im größten Business-Netzwerk der Welt an. Due to our privacy policy, only current members can send messages to people on ResearchGate. This file is licensed under the Creative Commons Attribution 3.0 Unported license. The established viral model system enables a dose-dependent and highly localized RNA-virus expression in a fully... Filamin C (FLNc) is mainly expressed in striated muscle cells where it localizes to Z-discs, myotendinous junctions and intercalated discs. Rationale: We hypothesized that diminished LA compliance and contractile function occur early during the development of heart failure with preserved ejection fraction (HFpEF) and impair overall cardiac performance. Briefpostadresse 37099 Göttingen . This review summarizes recent insight into the mechanisms behind how titin gene mutations cause hereditary cardiomyopathy and how titin prot... Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. Elevating NAD ⁺ by oral supple... Striated muscle responds to mechanical overload by rapidly up-regulating the expression of the cardiac ankyrin repeat protein, CARP, which then targets the sarcomere by binding to titin N2A in the I-band region. 2017 Jun;9(3):225-237. doi: 10.1007/s12551-017-0263-9. Wolfgang A. Linke Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres. Whether TTNtv are sufficient to cause DCM or require a second hit for DCM manifestation is an important clinical issue. Dahl salt-sensitive (DSS) rats and control rats were fed... Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Supplementary Figure Set for Unger et al., Acta Neuropathol Commun. Jedoch findet man molekulare Bewegungsvorgänge in allen Zelltypen. To date, the role of this interaction in the stress response of muscle remains poorly understood. Reinshof, REPORT, EUFABA N. Metayer '04 V. faba for sust. The prevalance of diastolic dysfunction is higher in females and associates with multiple comorbidities such as hypertension (HT), obesity, hypercholesterolemia (HC), and diabetes mellitus (DM). While increased passive stiffness of the myocardium is a suggested mechanism underlying diastolic dysfunction in these hearts, the contr... Reversible post-translational modifications of various cardiac proteins regulate the mechanical properties of the cardiomyocytes and thus modulate the contractile performance of the heart. Various professional articles, publications and lectures on general corporate law related issues as well as capital markets subjects. entropic effect of the massive native titin polypeptide is lost. Diese Bewegungen werden durch spezielle Struktur- und Motorproteine in den Muskelzellen ermöglicht. University students and faculty, institute members, and independent researchers, Technology or product developers, R&D specialists, and government or NGO employees in scientific roles, Health care professionals, including clinical researchers, Journalists, citizen scientists, or anyone interested in reading and discovering research. Aims Rathaus. Friedhof Junkerberg Heinrich-A.-Zachariä-Bogen 12 37077 Göttingen Kontakt: Telefon: 0551/400-5210 Telefax: 0551/400-5222 E-Mail: w.giesse@goettingen.de Accordingly, regulated protein decay is critical to maintain cardiac function. All rights reserved. English, German. Here we demonstrate that deficiency of SPRED2, an intracellular repressor of ERK-MAPK signaling markedly expressed in human heart, resulted in impaired autophagy, heart failure, and shortened lifespan. Universität Göttingen. Aims Here, we sought to advance cardiomyocyte maturation in engineered human myocardium (EHM) towards an adult phenotype under defined conditions. We previously reported that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from patients with a dilated cardiomyopathy (DCM) mutation, troponin T (TnT)-R173W, display sarcomere protein mi... Dysfunctional high-density lipoprotein (d-HDL) in chronic kidney disease is known to have a change in composition towards an endothelial-damaging phenotype, amongst others, via the accumulation of symmetric dimethylarginine. The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein titin, which is a scaffolding filament, signaling platform, and provider of passive tension and elasticity in myocytes. PmtA catalyzes the successive three-step N -... Background: We therefore investigated the influence of CX3CR1 ablation in the mode... Regulation of chemokine receptors and the corresponding chemokines in the spleen of Coxsackievirus B3-infected mice. Its mission is to provide high-quality human heart tissue for research into the molecular basis of human heart failure by working collaboratively with experts in this field. Indeed, there is a tight link in terms of shared risk factors and mechanisms... AimsOur aim was to investigate the effect of nitric oxide (NO)-independent activation of soluble guanylyl cyclase (sGC) on cardiomyocyte function in a hypertensive animal model with diastolic dysfunction and in biopsies from human heart failure with preserved ejection fraction (HFpEF).Methods
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